This was a subject that just popped into my head and I thought I’d put down my supposition on why this disease occurs. I can’t think of a treatment right now but understanding the why is one step closer to beating ME as far as I am concerned.
Now the way I look at it this, this disease which results in lethargy, muscle weakness, headaches etc. basically an inability for the person affected to perform simple daily activities, is a dibilatating disease.
So we need to look at the base, the root for all energy prodcution. In humans the process is respiration. So what is a common denomenator in respiration? Oxygen. Where or what uses Oxygen? Cells (duh?)
OK, within all cells what sub-component directly or indirectly react with O2 as part of the respiration process?
Answer – Mitochondria?
Mitochondria are interesting beasts, they are to all extents, domesticated bacteria, that produce ATP that is combined with other compounds and oxidized to produce energy for the host cell. In our case this occurs in all cells (i think) including neurons.
So what can affect this process? Well it’s not a big leap to see that mitochondria could be infected by Bacteriophages.
Bacteriophages are viruses that can infect bacteria. They have 2 methods of replication one resulting in the destruction of the host cell the other not. A destructive phage could be the cause but I’d put my money on a non-destructive phage that has inserted viral DNA into the mitochondria and affected the structure or function of infected mitochondria with respect to ATP production, creating a lysogenic cell.
So how can you treat this? Is this supposition even plausible or correct? I honestly don’t know. However the reason for looking at this subject and asking myself the question is a simple one. Family.
My mother has been diagnosed with …, well no-ones sure but after a trip to Florida last year, she became ill a month or so after returning from the holiday. Symptoms then elevated to fitting and memory issues. Currently with treatment this is still a problem for her she’s lethargic to a degree and she also has Foreign Accent Syndrome. This is the kind of affliction you hear associated with a stroke. However everything form the tests currently taken suggest not.
The doctor’s still hold the belief that stress could be a cause but have currently diagnosed her with some form of neurological disease.
Funny that this only appears at the age of 50 and after a trip to a forgeign country and an illness within a month of returning…stress my arse.
Personally, I have the feeling that this is due to some form of infection. It’s a long shot but I think it possible my mother’s health problems are the direct result of a bacteriophage, resulting in neurodegeneration.
The next step? More research, it helps to have an agile and open mind. I could well be entirely wrong, which I have to always bear in mind.